KHS101 hydrochloride
| CAS号 | 1784282-12-7 | 货号 | BCP30178 |
| 中文名 | KHS101 hydrochloride | ||
| 英文名 | KHS101 hydrochloride | ||
| 中文别名 | |||
| 英文别名 | KHS-101 hydrochloride; KHS 101 hydrochloride; KHS-101 HCl; KHS 101 HCl; KHS101 HCl; | ||
| 分子式 | C18H22ClN5S | 分子量 | 375.92 |
| 生物活性 | KHS101 hydrochloride is an inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It acts by selectively inducing neuronal differentiation and apoptotic cell death in breast cancer.KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM); works indirectly on HIF complex formation by destabilizing both TACC3 and the HIF component HIF-1α, decreases TACC3 levels in cells and regulates HIF gene expression; significantly increases neuronal differentiation in rats in vivo. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | HIF | ||
结构式
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