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KHS101 hydrochloride 结构式

KHS101 hydrochloride

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货号 :BCP30178CAS号 :1784282-12-7纯度:98%
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  • 基本信息与产品描述
CAS号 1784282-12-7 货号 BCP30178
中文名 KHS101 hydrochloride
英文名 KHS101 hydrochloride
中文别名
英文别名 KHS-101 hydrochloride; KHS 101 hydrochloride; KHS-101 HCl; KHS 101 HCl; KHS101 HCl;
SMILES CC(C)CNC1=NC(NCC2=CSC(C3=CC=CC=C3)=N2)=NC=C1.[H]Cl
化学名称
分子式 C18H22ClN5S 分子量 375.92
纯度 98% 配送 惯例下常温包邮
产品描述 KHS101 hydrochloride is an inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It acts by selectively inducing neuronal differentiation and apoptotic cell death in breast cancer.KHS-101 (KHS101) is a small molecule that selectively induces a neuronal differentiation phenotype, induces neuronal differentiation in cultured hippocampal neural progenitor cells (NPCs) by interacting with TACC3 (EC50=1 uM); works indirectly on HIF complex formation by destabilizing both TACC3 and the HIF component HIF-1α, decreases TACC3 levels in cells and regulates HIF gene expression; significantly increases neuronal differentiation in rats in vivo.
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