Lofexidine
CAS No. | 31036-80-3 | Cat. No. | BCP30596 |
Name | Lofexidine | ||
Synonyms | Lofexidinum;Britlofex; | ||
Formula | C11H12Cl2N2O | M. Wt | 259.13 |
Description | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992.[A33084] It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hypertension than clonidine.[T210] Lofexidine was then repurposed for the treatment of opioid withdrawal, as it was seen to be more economical and have fewer side effects than clonidine. | ||
Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
Targets | Adrenergic Receptor |
Structure
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