Glumetinib
| CAS号 | 1642581-63-2 | 货号 | BCP31155 |
| 中文名 | Glumetinib | ||
| 英文名 | Glumetinib | ||
| 中文别名 | |||
| 英文别名 | SCC244; SC-C244; SCC 244; | ||
| 分子式 | C21H17N9O2S | 分子量 | 459.49 |
| 生物活性 | Glumetinib is a novel, potent and highly selective inhibitor of c-Met in MET-dependent cancer models. SCC244 showed subnanomolar potency against c-Met kinase activity and high selectivity versus 312 other tested protein kinases, making it one of the most selective c-Met inhibitors described to date. Moreover, this inhibitor profoundly and specifically inhibits c-Met signal transduction and thereby suppresses the c-Met-dependent neoplastic phenotype of tumor and endothelial cells. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | c Met | ||
结构式
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