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| CAS号 | 1642581-63-2 | 货号 | BCP31155 |
| 中文名 | Glumetinib | ||
| 英文名 | Glumetinib | ||
| 中文别名 | |||
| 英文别名 | SCC244; SC-C244; SCC 244; | ||
| SMILES | CN1C=C(C=N1)C2=CN3C(=NC=C3S(=O)(=O)N4C5=C(C=N4)N=CC(=C5)C6=CN(N=C6)C)C=C2 | ||
| 化学名称 | |||
| 分子式 | C21H17N9O2S | 分子量 | 459.49 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Glumetinib is a novel, potent and highly selective inhibitor of c-Met in MET-dependent cancer models. SCC244 showed subnanomolar potency against c-Met kinase activity and high selectivity versus 312 other tested protein kinases, making it one of the most selective c-Met inhibitors described to date. Moreover, this inhibitor profoundly and specifically inhibits c-Met signal transduction and thereby suppresses the c-Met-dependent neoplastic phenotype of tumor and endothelial cells. | ||
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