SOMG-833 HCl 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP49025CAS号：1268264-10-3纯度：98%

在线咨询

购买咨询

全国免运费！免费咨询：400-099-8200 或手机联系：13472751340

* 必填项

请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。

* Required Fields.

Please complete the form below and we will contact you shortly.

* Required Fields.

Please complete the form below and we will contact you shortly.

CAS号	1268264-10-3	货号	BCP49025
中文名	SOMG-833 HCl
英文名	SOMG-833 HCl
中文别名
英文别名	SOMG 833 HCl; SOMG833 HCl; SOMG-833 Hydrochloride; SOMG833 Hydrochloride; SOMG 833 Hydrochloride; Zgwatinib Hydrochloride; Zgwatinib HCl;
SMILES	CN1CCN(CC1)C2=CC3=C(C=C(C=C3NCC4=CC(=CC=C4)[N+](=O)[O-])C(F)(F)F)N=C2.Cl
化学名称
分子式	C22H23ClF3N5O2	分子量	481.9
纯度	98%	配送	惯例下常温包邮
产品描述	SOMG-833 HCl is a selective c-MET inhibitor that acts by blocking c-MET dependent neoplastic effects and exerting antitumor activity.SOMG-833 is a potent, selective, ATP-competitive c-MET inhibitor with IC50 of 0.93 nM; displays >10,000-fold selectivity over panel of 20 kinases, including c-MET family member RON and highly homologous kinase AXL; significantly inhibits c-MET phosphorylation and the proliferation of c-MET-dependent EBC-1, MKN-45, SNU-5, and BaF3/TPR-MET cell lines with IC50 of 0.160-0.457 uM, through G1/S cell cycle arrest; demonstrates remarkable antitumor efficacy in vivo.