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| CAS号 | 1000873-98-2 | 货号 | BCP28549 |
| 中文名 | ARQ 197 | ||
| 英文名 | ARQ 197 | ||
| 中文别名 | |||
| 英文别名 | Tivantinib;ARQ-197;ARQ197; | ||
| SMILES | C1CC2=CC=CC3=C2N(C1)C=C3[C@H]4[C@@H](C(=O)NC4=O)C5=CNC6=CC=CC=C65 | ||
| 化学名称 | |||
| 分子式 | C23H19N3O2 | 分子量 | 369.42 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | ARQ-197 is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis. | ||
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