ARQ 197
| CAS号 | 1000873-98-2 | 货号 | BCP28549 |
| 中文名 | ARQ 197 | ||
| 英文名 | ARQ 197 | ||
| 中文别名 | |||
| 英文别名 | Tivantinib;ARQ-197;ARQ197; | ||
| 分子式 | C23H19N3O2 | 分子量 | 369.42 |
| 生物活性 | ARQ-197 is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity. c-Met inhibitor ARQ 197 binds to the c-Met protein and disrupts c-Met signal transduction pathways, which may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met protein, the product of the proto-oncogene c-Met, is a receptor tyrosine kinase also known as hepatocyte growth factor receptor (HGFR); this protein is overexpressed or mutated in many tumor cell types and plays key roles in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | c Met | ||
结构式
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