Amitriptyline hydrochloride

CAS No.	549-18-8	Cat. No.	BCP31573
Name	Amitriptyline hydrochloride
Synonyms	Amitriptyline HCl;Nortriptyline Impurity F;
Formula	C20H23N.HCl	M. Wt	313.87

Description	Amitriptyline Hydrochloride is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptive activities. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity. In the CNS the antinociceptive activity of this agent may involve high affinity binding to and inhibition of N-methyl-D-aspartate (NMDA) receptors and/or the enhancement of the action of serotonin at the spinal terminals of an opioid-mediated intrinsic analgesia system.
Pathways	Ion Channel/Membrane Transporter
Targets	Sodium Channel

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