Methyl leucylleucinate hydrochloride
| CAS No. | 6491-83-4 | Cat. No. | BCP31707 |
| Name | Methyl leucylleucinate hydrochloride | ||
| Synonyms | L-Leucyl-L-Leucine methyl ester (hydrochloride);H-LEU-LEU-OME HCl;Leu-Leu-ome HCl; | ||
| Formula | C13H27ClN2O3 | M. Wt | 294.82 |
| Description | L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4 It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells. | ||
| Pathways | Microbiology/Virology | ||
| Targets | HIV | ||
Structure
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