Milademetan tosylate monohydrate
| CAS No. | 2095625-97-9 | Cat. No. | BCP31919 |
| Name | Milademetan tosylate monohydrate | ||
| Synonyms | DS3032b; DS-3032b; DS 3032b; DS3032; DS-3032; DS 3032; | ||
| Formula | C37H44Cl2FN5O8S | M. Wt | 808.74 |
| Description | Milademetan, also known as DS-3032b, is a potent and selective MDM2 inhibitor with potential antineoplastic activity. Upon oral administration, MDM2 inhibitor DS-3032b binds to, and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apoptosis. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | Mdm2 | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.