DDD107498
| CAS No. | 1469439-69-7 | Cat. No. | BCP31981 |
| Name | DDD107498 | ||
| Synonyms | DDD-107498; DDD 107498; DDD 498; DDD-498; DDD498; MMV121; MMV-121; MMV 121; | ||
| Formula | C27H31FN4O2 | M. Wt | 462.57 |
| Description | DDD107498, also known as DDD 498, is a multiple-stage antimalarial agent that inhibits protein synthesis. DDD107498 demonstrates potential to address a variety of clinical needs, including single-dose treatment, transmission blocking and chemoprotection. DDD107498 was developed from a screening programme against blood-stage malaria parasites; its molecular target has been identified as translation elongation factor 2 (eEF2), which is responsible for the GTP-dependent translocation of the ribosome along messenger RNA, and is essential for protein synthesis. This discovery of eEF2 as a viable antimalarial drug target opens up new possibilities for drug discovery. | ||
| Pathways | Microbiology/Virology | ||
| Targets | Antiparasitics | ||
Structure
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