hVEGF-IN-1
| CAS号 | 1637443-98-1 | 货号 | BCP32794 |
| 中文名 | hVEGF-IN-1 | ||
| 英文名 | hVEGF-IN-1 | ||
| 中文别名 | |||
| 英文别名 | |||
| 分子式 | C34H43N7O2 | 分子量 | 581.75 |
| 生物活性 | hVEGF-IN-1 represses human VEGF-A translation and shows antitumor activity.hVEGF-IN-1 shows a significant specific interaction with the G-rich region within the 5′- untranslated regions (5′-UTR) of hVEGF-A mRNA and destabilizes the Gquadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 μM and binds to the hairpin DNA with a Kd of 21.2 μM. The G-rich sequence G774-G790 within the IRES-A of hVEGF-A’s 5′-UTR has been shown to be critical for the translation initiation activity of IRES-A. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | VEGFR | ||
结构式
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