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| CAS号 | 1637443-98-1 | 货号 | BCP32794 |
| 中文名 | hVEGF-IN-1 | ||
| 英文名 | hVEGF-IN-1 | ||
| 中文别名 | |||
| 英文别名 | |||
| SMILES | CCN(CC)CCOC1=CC=C(C=C1)NC2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4NC(=O)CCN5CCN(CC5)C | ||
| 化学名称 | |||
| 分子式 | C34H43N7O2 | 分子量 | 581.75 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | hVEGF-IN-1 represses human VEGF-A translation and shows antitumor activity.hVEGF-IN-1 shows a significant specific interaction with the G-rich region within the 5′- untranslated regions (5′-UTR) of hVEGF-A mRNA and destabilizes the Gquadruplex structure. hVEGF-IN-1 binds to the IRES-A (WT) with a Kd of 0.928 μM and binds to the hairpin DNA with a Kd of 21.2 μM. The G-rich sequence G774-G790 within the IRES-A of hVEGF-A’s 5′-UTR has been shown to be critical for the translation initiation activity of IRES-A. | ||
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