TAS-115 mesylate
| CAS号 | 1688673-09-7 | 货号 | BCP34015 |
| 中文名 | TAS-115 mesylate | ||
| 英文名 | TAS-115 mesylate | ||
| 中文别名 | |||
| 英文别名 | TAS 115 methanesulfonate;TAS-115 methanesulfonate;TAS115 mesylate; | ||
| 分子式 | C28H27FN4O7S2 | 分子量 | 614.66 |
| 生物活性 | TAS-115 is a c-MET and VEGFR inhibitor which is selective and specific in vitro. In vivo studies, TAS-115 suppressed the progression of MET-inactivated tumor completely through blocking angiogenesis without toxicity and it also induced marked tumor shrinkage and prolonged survival in animal model. In Dec 2013, Phase-I development was ongoing in Japan. In Dec 2014, Taiho Pharmaceutical completed a phase I trial for Solid tumours in Japan. In Apr 2016, preclinical data was presented. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | c Met VEGFR | ||
结构式
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