MS31
| CAS No. | 2366264-12-0 | Cat. No. | BCP34903 |
| Name | MS31 | ||
| Synonyms | MS-31; MS31; | ||
| Formula | C20H27N3O2 | M. Wt | 341.45 |
| Description | MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells. | ||
| Pathways | Epigenetics | ||
| Targets | Epigenetic Reader Domain | ||
Structure
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