ASLAN003
| CAS No. | 1035688-66-4 | Cat. No. | BCP36999 |
| Name | ASLAN003 | ||
| Synonyms | ASLAN 003; ASLAN-003; | ||
| Formula | C19H14F2N2O3 | M. Wt | 356.33 |
| Description | ASLAN003 is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC50 of 35 nM for human DHODH enzyme. ASLAN003 inhibits protein synthesis via activation of AP-1 transcription factors. ASLAN003 induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA/RNA Synthesis | ||
Structure
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