CX5461 dihydrochloride
| CAS号 | CX-54612HCl | 货号 | BCP37427 |
| 中文名 | CX5461 dihydrochloride | ||
| 英文名 | CX5461dihydrochloride | ||
| 中文别名 | |||
| 英文别名 | CX-5461 dihydrochloride;CX-5461 2HCl; | ||
| 分子式 | C27H29Cl2N7O2S | 分子量 | 586.54 |
| 生物活性 | CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM).CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA/RNA Synthesis | ||
结构式
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