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CX5461dihydrochloride 结构式

CX5461 dihydrochloride

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货号 :BCP37427CAS号 :CX-54612HCl纯度:98%
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  • 基本信息与产品描述
CAS号 CX-54612HCl 货号 BCP37427
中文名 CX5461 dihydrochloride
英文名 CX5461dihydrochloride
中文别名
英文别名 CX-5461 dihydrochloride;CX-5461 2HCl;
SMILES CC1=NC=C(CNC(C2=C3N(C4=NC(N5CCN(CCC5)C)=CC=C4C2=O)C6=C(S3)C=CC=C6)=O)N=C1.[2 HCl]
化学名称
分子式 C27H29Cl2N7O2S 分子量 586.54
纯度 98% 配送 惯例下常温包邮
产品描述 CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM).CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation.
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