AVN-944 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP23877CAS号：297730-17-7纯度：98%

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CAS号	297730-17-7	货号	BCP23877
中文名	AVN-944
英文名	AVN-944
中文别名
英文别名	AVN 944; AVN944; VX944; VX 944; VX-944;
SMILES	CCC(CC#N)OC(=O)NC(C)C1=CC(=CC=C1)NC(=O)NC2=CC(=C(C=C2)C3=CN=CO3)OC
化学名称
分子式	C25H27N5O5	分子量	477.51
纯度	98%	配送	惯例下常温包邮
产品描述	AVN-944 (VX-944) is an orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. Inhibition of IMPDH deprives cancer cells of GTP, resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only. IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies.