AVN-944
| CAS号 | 297730-17-7 | 货号 | BCP23877 |
| 中文名 | AVN-944 | ||
| 英文名 | AVN-944 | ||
| 中文别名 | |||
| 英文别名 | AVN 944; AVN944; VX944; VX 944; VX-944; | ||
| 分子式 | C25H27N5O5 | 分子量 | 477.51 |
| 生物活性 | AVN-944 (VX-944) is an orally available, synthetic small molecule with potential antineoplastic activity. AVN944 inhibits inosine monosphosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanosine triphosphate (GTP), a purine molecule required for DNA and RNA synthesis. Inhibition of IMPDH deprives cancer cells of GTP, resulting in disruption of DNA and RNA synthesis, inhibition of cell proliferation, and the induction of apoptosis. AVN944 appears to have a selective effect on cancer cells in that deprivation of GTP in normal cells results in a temporary slowing of cell growth only. IMPDH is overexpressed in some cancer cells, particularly in hematological malignancies. | ||
| 信号通路 | Protease/Metabolic Enzyme Cell Cycle/DNA Damage Apoptosis Pathway | ||
| 靶 点 | DNA/RNA Synthesis Caspase Bcl2 | ||
结构式
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