Atpenin A5
| CAS No. | 119509-24-9 | Cat. No. | BCP38457 |
| Name | Atpenin A5 | ||
| Synonyms | Antibiotic FO-125A5; | ||
| Formula | C15H21Cl2NO5 | M. Wt | 366.24 |
| Description | Atpenin A5 is an inhibitor of SDHB, SDHC and SDHD. It is an antifungal antibiotic and an ubiquinone-binding site inhibitor of succinate dehydrogenase with IC50s of 12 nM for nematode and IC50s of 3.7 nM for mammalian mitochondria. Atpenin A5 is the most effective inhibitor against complex II from all the atpenins and has been shown to protect against cardiac-reperfusion injury in rat studies through the stimulation of mitochondrial KATP channels. | ||
| Pathways | Microbiology/Virology | ||
| Targets | Antibiotic | ||
Structure
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