Porfiromycin
| CAS No. | 801-52-5 | Cat. No. | BCP38467 |
| Name | Porfiromycin | ||
| Synonyms | Regamycin;Methylmitomycin;N-Methylmitomycin C;Methyl mitomycin C; | ||
| Formula | C16H20N4O5 | M. Wt | 348.35 |
| Description | Porfiromycin is an N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species. Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis. Porfiromycin is preferentially toxic to hypoxic cells. | ||
| Pathways | Microbiology/Virology | ||
| Targets | Antibiotic | ||
Structure
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