BI-1467335
| CAS No. | 1478364-40-7 | Cat. No. | BCP42731 |
| Name | BI-1467335 | ||
| Synonyms | PXS-4728A; PXS4728A; PXS 4728A; BI1467335; BI 1467335; | ||
| Formula | C15H21FN2O2 | M. Wt | 280.34 |
| Description | BI-1467335 is a SSAO/VAP inhibitor potentially for the treatment of non-alcoholic steatohepatitis. VAP-1/SSAO contributes to the migration of neutrophils during acute lung inflammation, pulmonary infection and airway hyperractivity. Selective VAP-1/SSAO inhibition by PXS-4728A diminished leukocyte rolling and adherence induced by CXCL1/KC. Inhibition of VAP-1/SSAO also dampened the migration of neutrophils to the lungs in response to LPS, Klebsiella pneumoniae lung infection and CLP induced sepsis; whilst still allowing for normal neutrophil defense function, resulting in increased survival. | ||
| Pathways | Others Pathway | ||
| Targets | Others | ||
Structure
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