WS-12
| CAS No. | 68489-09-8 | Cat. No. | BCP43788 |
| Name | WS-12 | ||
| Synonyms | WS 12; WS12; | ||
| Formula | C18H27NO2 | M. Wt | 289.42 |
| Description | WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 = 193 nM). WS-12 robustly activated TRPM8 in low micromolar concentrations (EC50 12+/-5 microM) thereby displaying a higher potency and efficacy compared to menthol (EC50 196+/-22 microM). The selectivity profile of WS-12, its several-fold higher potency and around two-fold increase in efficacy compared to menthol warrants its potential utility for therapy in chronic neuropathic pain states and as a diagnostic probe in prostate cancer. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | TRP Channel | ||
Structure
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