Quisinostat HCl
| CAS号 | 1083078-98-1 | 货号 | BCP44306 |
| 中文名 | Quisinostat HCl | ||
| 英文名 | Quisinostat HCl | ||
| 中文别名 | |||
| 英文别名 | Quisinostat hydrochloride;JNJ26481585; JNJ-26481585; JNJ 26481585; | ||
| 分子式 | C21H27ClN6O2 | 分子量 | 430.94 |
| 生物活性 | Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation. | ||
| 信号通路 | Cell Cycle/DNA Damage Epigenetics | ||
| 靶 点 | HDAC | ||
结构式
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