Quisinostat HCl 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP44306CAS号：1083078-98-1纯度：98%

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CAS号	1083078-98-1	货号	BCP44306
中文名	Quisinostat HCl
英文名	Quisinostat HCl
中文别名
英文别名	Quisinostat hydrochloride;JNJ26481585; JNJ-26481585; JNJ 26481585;
SMILES	CN1C=C(C2=CC=CC=C21)CNCC3CCN(CC3)C4=NC=C(C=N4)C(=O)NO.Cl
化学名称
分子式	C21H27ClN6O2	分子量	430.94
纯度	98%	配送	惯例下常温包邮
产品描述	Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation.