Resminostat hydrochloride 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP39644CAS号：1187075-34-8纯度：98%

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CAS号	1187075-34-8	货号	BCP39644
中文名	Resminostat hydrochloride
英文名	Resminostat hydrochloride
中文别名
英文别名	Resminostat HCl;
SMILES	CN(C)CC1=CC=C(C=C1)S(=O)(=O)N2C=CC(=C2)C=CC(=O)NO.Cl
化学名称
分子式	C16H20ClN3O4S	分子量	385.86
纯度	98%	配送	惯例下常温包邮
产品描述	Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6. As an inhibitor of HDACs, resminostat also inhibits HDAC8 with a weak activity (IC50=877nM). 5μM resminostat induces the acetylation of histone H4 in U266 myeloma cells. 10μM resminostat completely suppresses the cell growth in human myeloma cell lines, such as OPM-2, RPMI-8226 and U266. This inhibition is proved to be caused by the induction of apoptosis. In primary myeloma cells, resminostat also induces apoptosis of cells. Besides that, resminostat is proved to downregulate the expression of cell cycle proteins, including phosphorylated Rb, cdc25a, cyclin D1, Cdk4 and p53. In addition, resminostat is reported to be well tolerated, have no unexpected toxicities and do not cause clinically significant myelosuppression in the first-human study.