CL 316243

  • Chemical Properties
CAS No. 138908-40-4 Cat. No. BCP44544
Name CL 316243
Synonyms CL 316243; CL316243; CL-316,243; CL 316,243; CL316,243. HP 186; HP-186; HP186;
Formula C20H18ClNO7.2Na M. Wt 465.79
  • Biological Activity
Description CL-316243 is a potent and highly selective β3-adrenoceptor agonist (EC50 = 3 nM); > 10000-fold selective over β1 and β2 receptors. CL-316243 restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice. CL-316,243 enhances insulin-stimulated glucose disposal in nonobese rats. CL 316243 possesses anti-obesity and anti-diabetic effects and consequently may be useful for treating obesity as well as non-insulin-dependent diabetes mellitus in obese persons, without causing excessive side effects.
Pathways Neuro Signaling Pathway GPCR/G Protein 
Targets Adrenergic Receptor 

Structure

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