Crisdesalazine
| CAS No. | 927685-43-6 | Cat. No. | BCP44811 |
| Name | Crisdesalazine | ||
| Synonyms | AAD-2004; AAD2004; AAD 2004; | ||
| Formula | C16H14F3NO3 | M. Wt | 325.28 |
| Description | Crisdesalazine, also known as AAD-2004, is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor potentially for the treatment of Alzheimer's type dementia, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Arthritis, Depression, Diabetes and Pancreatitis. AAD-2004 markedly suppressed neuronal loss and neuritic atrophy, and partially reversed depleted expression of calbindin in the brain of Tg-beta-CTF99/B6. AAD-2004 reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and increasing life span. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Prostaglandin Receptor | ||
Structure
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