Begacestat
| CAS No. | 769169-27-9 | Cat. No. | BCP46406 |
| Name | Begacestat | ||
| Synonyms | GSI-953; GSI953; GSI 953; | ||
| Formula | C9H8ClF6NO3S2 | M. Wt | 391.74 |
| Description | Begacestat, also known as GSI-953, is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. Begacestat inhibits Abeta production with low nanomolar potency in cellular and cell-free assays of gamma-secretase function. | ||
| Pathways | Protease/Metabolic Enzyme Neuro Signaling Pathway Wnt/Stem Cell | ||
| Targets | Gamma secretase Amyloid β | ||
Structure
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