8,9-Eet

CAS No.	81246-85-7	Cat. No.	BCP47805
Name	8,9-Eet
Synonyms	(+/-)8,9-EET;8,9-Epoxyeicosatrienoic acid;
Formula	C20H32O3	M. Wt	320.47

Description	(±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid. (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. It activates PPARα in HEK293 cells when used at a concentration of 1 µM but inhibits NF-κB activity induced by IL-1β in a PPARα-dependent and -independent fashion. It is also a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 µM. (8S,9R)-EET (1 µg/kg), but not (8R,9S)-EET, reduces the glomerular filtration rate (GFR) through COX-dependent pre-glomerular vasoconstriction in rats.
Pathways	Protease/Metabolic Enzyme
Targets	Cytochrome P450

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