PF-05274857 HCl
| CAS No. | 1613439-62-5 | Cat. No. | BCP48085 |
| Name | PF-05274857 HCl | ||
| Synonyms | PF-5274857 HCl; PF-5274857 hydrochloride;PF05274857 HCl;PF 05274857 HCl; PF-5274857 hydrochloride; | ||
| Formula | C20H26Cl2N4O3S | M. Wt | 473.42 |
| Description | PF 5274857 hydrochloride is a high affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM). Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant. | ||
| Related Products | 1373615-35-0（PF-5274857） | ||
| Pathways | GPCR/G Protein | ||
| Targets | Smoothened/Smo | ||
Structure
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