Saridegib hydrochloride

CAS No.	1169829-40-6	Cat. No.	BCP21080
Name	Saridegib hydrochloride
Synonyms	Saridegib HCl;IPI 926 hydrochloride;IPI 926; IPI-926; IPI926; Saridegib; Patidegip;
Formula	C29H48N2O3S.HCl	M. Wt	541.23

Description	Saridegib, also known as IPI-926, is an orally bioavailable, cyclopamine-derived (for structure comparison see Fig 1) inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, Hedgehog pathway inhibitor IPI-926 binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations.
Pathways	Wnt/Stem Cell
Targets	Hedgehog

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