Mavorixafor
| CAS No. | 558447-26-0 | Cat. No. | BCP07108 |
| Name | Mavorixafor | ||
| Synonyms | AMD11070; AMD-11070; AMD 11070;AMD 070; AMD070; X4P-001; X4P 001; X4P001; AMD-070; | ||
| Formula | C21H27N5 | M. Wt | 349.48 |
| Description | AMD-070(AMD 070) is useful for Anti HIV.AMD-070 is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, and inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.AMD11070 is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF-1α ligand binding (IC50 = 12.5 ± 1.3 nM), inhibits SDF-1 mediated calcium flux (IC50 = 9.0 ± 2.0 nM) and SDF-1α mediated activation of the CXCR4 receptor as measured by a Eu-GTP binding assay (IC50 =39.8 ± 2.5 nM) or a [(35)S]-GTPγS binding assay (IC50 =19.0 ± 4.1 nM), and inhibits SDF-1α stimulated chemotaxis (IC50 =19.0 ± 4.0 nM). AMD11070 abrogates melanoma cell migration and is significantly more effective than AMD3100. AMD11070 represents a novel therapeutic strategy for both B-RAF wild-type and mutated melanomas. | ||
| Related Products | 880549-30-4（Mavorixafor hydrochloride） 2309699-17-8（Mavorixafor trihydrochloride） | ||
| Pathways | GPCR/G Protein | ||
| Targets | CXCR | ||
Structure
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