2-CL-IB-MECA

CAS No.	163042-96-4	Cat. No.	BCP06430
Name	2-CL-IB-MECA
Synonyms	CF102; CF-102; CF 102; Chloro-IB-MECA; CI-IB-MECA; Namodenoson;
Formula	C18H18ClIN6O4	M. Wt	544.73

Description	2-Cl-IB-MECA, also known as CF-102 or Namodenoson, is an orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Adenosine A3 receptor agonist CF102 selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. A3AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of various solid tumor cell types, including hepatocellular carcinoma (HCC) cells, and plays an important role in cellular proliferation.
Pathways	GPCR/G Protein
Targets	Adenosine Receptor

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