2-CL-IB-MECA
Data Sheet
For research use only. Not for human use.
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| CAS No. | 163042-96-4 | Cat. No. | BCP06430 |
| Name | 2-CL-IB-MECA | ||
| Synonyms | CF102; CF-102; CF 102; Chloro-IB-MECA; CI-IB-MECA; Namodenoson; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C18H18ClIN6O4 | M. Wt | 544.73 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | 2-Cl-IB-MECA, also known as CF-102 or Namodenoson, is an orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Adenosine A3 receptor agonist CF102 selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. A3AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of various solid tumor cell types, including hepatocellular carcinoma (HCC) cells, and plays an important role in cellular proliferation. | ||
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