盐酸吉西他滨
| CAS号 | 122111-03-9 | 货号 | BCP04160 |
| 中文名 | 盐酸吉西他滨 | ||
| 英文名 | Gemcitabine hydrochloride | ||
| 中文别名 | 盐酸吉西他宾;吉西他宾盐酸盐; | ||
| 英文别名 | Gemcitabine HCl; LY188011 hydrochloride;LY 188011 hydrochloride;LY-188011 hydrochloride; | ||
| 分子式 | C9H12ClF2N3O4 | 分子量 | 299.66 |
| 生物活性 | Gemcitabine induced NF-κB activity in BxPC-3, PANC-1, and MIA PaCa-2 cells and decreased the level of the NF-κB inhibitor IκBα in BxPC-3 and PANC-1 cells. Treatment of BxPC-3 cells with low dose Gemcitabine for 48 hours results in a dose-dependent increase in NF-κB binding. In contrast, NF-κB DNA binding is decreased in BxPC-3 cells treated with the higher Gemcitabine doses for 48 h; however, 24-h treatment with these higher doses increases NF-κB binding in BxPC-3 cells. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA/RNA Synthesis Antimetabolite | ||
结构式
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