环磷酰胺一水物
| CAS号 | 6055-19-2 | 货号 | BCP22663 |
| 中文名 | 环磷酰胺一水物 | ||
| 英文名 | Cyclophosphamide hydrate | ||
| 中文别名 | 环磷酰胺一水合物; | ||
| 英文别名 | Cyclophosphamide monohydrate; | ||
| 分子式 | C7H17Cl2N2O3P | 分子量 | 279.1 |
| 生物活性 | Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.Cyclophosphamide is used as chemotherapy and to suppress the immune system. As chemotherapy it is used to treat lymphoma, multiple myeloma, leukemia, ovarian cancer, breast cancer, small cell lung cancer, neuroblastoma, and sarcoma. As an immune suppressor it is used in nephrotic syndrome and following organ transplant. It is taken by mouth or injection into a vein. The main effect of cyclophosphamide is due to its metabolite phosphoramide mustard. This metabolite is only formed in cells that have low levels of ALDH. Phosphoramide mustard forms DNA crosslinks both between and within DNA strands at guanine N-7 positions (known as interstrand and intrastrand crosslinkages, respectively). This is irreversible and leads to cell apoptosis. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA Alkylator/Crosslinker | ||
结构式
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