Gemcitabine
| CAS No. | 95058-81-4 | Cat. No. | BCP22713 |
| Name | Gemcitabine | ||
| Synonyms | DDFC ;LY-188011; LY 188011; LY188011;NSC 613327;NSC613327;NSC-613327; | ||
| Formula | C9H11F2N3O4 | M. Wt | 263.2 |
| Description | Gemcitabine is an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | DNA/RNA Synthesis Antimetabolite | ||
Structure
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