Alendronate sodium trihydrate

CAS No.	121268-17-5	Cat. No.	BCP22746
Name	Alendronate sodium trihydrate
Synonyms	Alendronate monosodium trihydrate;
Formula	C4H13NNaO7P2	M. Wt	325.12

Description	Alendronate sodium is the sodium salt of alendronate, a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced. Check for active clinical trials or closed clinical trials using this agent.
Pathways	Others Pathway
Targets	Others

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