Topotecan HCl
| CAS No. | 119413-54-6 | Cat. No. | BCP00930 |
| Name | Topotecan HCl | ||
| Synonyms | Hycamtin;Nogitecan hydrochlorid;NSC-609699;NSC 609699;NSC609699; | ||
| Formula | C23H23N3O5.HCl | M. Wt | 457.91 |
| Description | Stronger drug activity of Topotecan is observed for DU-145 Luc and MCF-7 Luc cells.Topotecan causes cytotoxicity during the course of DNA replication by stabilizing the covalent complex between topoisomerase I and DNA and preventing the religation of enzyme-linked single-strand DNA break. Topotecan stabilizes topoisomerase I/DNA cleavable complexes in radiation-resistant human B-lineage acute lymphoblastic leukemia (ALL) cells, causes rapid apoptotic cell death despite high-level expression of bcl-2 protein, and inhibits ALL cell clonogenic growth in a dose-dependent fashion. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Topoisomerase | ||
Structure
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