BMS-777607
| CAS号 | 1025720-94-8 | 货号 | BCP02303 |
| 中文名 | BMS-777607 | ||
| 英文名 | BMS-777607 | ||
| 中文别名 | |||
| 英文别名 | 1196681-44-3;BMS817378; BMS 817378; BMS-817378; BMS777607;BMS 777607; ASLAN 002; ASLAN-002; ASLAN002; | ||
| 分子式 | C25H19ClF2N4O4 | 分子量 | 512.89 |
| 生物活性 | BMS-777607, also known as BMS-817378 and ASLAN-002, a Met tyrosine kinase inhibitor, is an inhibitor of MET tyrosine kinase with potential antineoplastic activity. MET tyrosine kinase inhibitor BMS-777607 binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis. | ||
| 上下游产品 | 1196681-44-3 （BMS 777607） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | TAM Receptor c Met | ||
结构式
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