GW843682X
| CAS No. | 660868-91-7 | Cat. No. | BCP27639 |
| Name | GW843682X | ||
| Synonyms | GW 843682X; GW-843682X; | ||
| Formula | C22H18F3N3O4S | M. Wt | 477.46 |
| Description | GW843682X is a selective inhibitor of polo-like kinase 1 (PLK1) and polo-like kinase 3 (PLK3) (IC50 values are 2.2 and 9.1 nM respectively). GW843682X inhibited the proliferation and induced apoptosis of 5-8F cells in a dose-dependent manner (IC50=62.5-125nmol/L). GW843682X exhibited remarkable cytotoxic effects on nasopharyngeal carcinoma 5-8F cells by down-regulating IAP gene expression, suggesting that GW843682X may become a novel therapeutic agent for nasopharyngeal carcinoma. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | PLK | ||
Structure
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