BMS-754807
| CAS No. | 1001350-96-4 | Cat. No. | BCP01926 |
| Name | BMS-754807 | ||
| Synonyms | BMS 754807;BMS754807; | ||
| Formula | C23H24FN9O | M. Wt | 461.49 |
| Description | BMS-754807 is an orally bioavailable antagonist of human insulin-like growth factor type I receptor (IGF-1R) with potential antineoplastic activity. IGF-1R antagonist BMS-7548077 binds to IGF-1R, preventing IGF-1 ligand binding and activation of IGF-1R-mediated signaling pathways; inhibition of IGF-1R-mediated signaling pathways may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R is a receptor tyrosine kinase expressed on most tumor cells and is involved in mitogenesis, angiogenesis, and tumor cell survival. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Insulin Receptor IGF1R | ||
Structure
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