Acitretin
| CAS No. | 55079-83-9 | Cat. No. | BCP02080 |
| Name | Acitretin | ||
| Synonyms | Ro 10-1670; Ro-10-1670; Ro10-1670; Ro 10-1670/000; U0279;Soriatane; | ||
| Formula | C21H26O3 | M. Wt | 326.43 |
| Description | Acitretin is a second generation retinoid. It is taken orally, and is typically used for psoriasis. It is a metabolite of etretinate, which was used prior to the introduction of acitretin. Etretinate was discontinued because it had a narrow therapeutic index as well as a long elimination half-life (t1/2=120 days), making dosing difficult. In contrast, acitretin’s half-life is approximately 2 days. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | RAR/RXR | ||
Structure
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