1 NM-PP1
| CAS No. | 221244-14-0 | Cat. No. | BCP09491 |
| Name | 1 NM-PP1 | ||
| Synonyms | 1-Naphthylmethyl-PP1;NM-PP1;Mutant Kinases Inhibitor II; 1NM-PP1; 1NM PP1; 1NMPP1;1-NM-PP1;PP1 Analog II; | ||
| Formula | C20H21N5 | M. Wt | 331.41 |
| Description | 1 NM-PP1 is a potent Mutant Kinases Inhibitor.1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 μM, respectively). The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 3.2 nM for c-Fyn-as1 versus 1.0 μM for c-Fyn; 5.0 nM for Cdk2-as1 versus 29 μM for Cdk2; 8.0 nM for CAMKII-as1 versus 24 μM for CAMKII). This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Src/Bcr Abl | ||
Structure
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