Mevastatin
| CAS No. | 73573-88-3 | Cat. No. | BCP12101 |
| Name | Mevastatin | ||
| Synonyms | Compactin;ML-236B;ML 236B;ML236B; | ||
| Formula | C23H34O5 | M. Wt | 390.52 |
| Description | Mevastatin induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27. Mevastatin suppresses TNF-induced NF-κB activation (IC50 = ~17 uM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | HMGCR | ||
Structure
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