盐酸环胞苷
| CAS号 | 10212-25-6 | 货号 | BCP12373 |
| 中文名 | 盐酸环胞苷 | ||
| 英文名 | Ancitabine hydrochloride | ||
| 中文别名 | 环胞甙盐酸盐; | ||
| 英文别名 | Cyclocytidine hydrochloride;Cyclocytidine HCl;Cyclo-CMP hydrochloride; | ||
| 分子式 | C9H12ClN3O4 | 分子量 | 261.66 |
| 生物活性 | Ancitabine Hydrochloride is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. Cytarabine agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Compared to cytarabine, a more prolonged, consistent cytarabine-mediated therapeutic effect may be achieved with ancitabine because of the slow hydrolytic conversion of ancitabine to cytarabine. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | DNA/RNA Synthesis | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！