WIKI4
| CAS号 | 838818-26-1 | 货号 | BCP15357 |
| 中文名 | WIKI4 | ||
| 英文名 | WIKI4 | ||
| 中文别名 | |||
| 英文别名 | WIKI 4; WIKI-4; | ||
| 分子式 | C29H23N5O3S | 分子量 | 521.59 |
| 生物活性 | WIKI4 is a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. WIKI4 inhibits expression of ß-catenin target genes and cellular responses to Wnt/ß-catenin signaling in cancer cell lines as well as in human embryonic stem cells. WIKI4 mediates its effects on Wnt/ß-catenin signaling by inhibiting the enzymatic activity of TNKS2, a regulator of AXIN ubiquitylation and degradation. While TNKS has previously been shown to be the target of small molecule inhibitors of Wnt/ß-catenin signaling, WIKI4 is structurally distinct from previously identified TNKS inhibitors. | ||
| 信号通路 | Wnt/Stem Cell | ||
| 靶 点 | Beta catenin | ||
结构式
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